Publications:
- Infectious Diseases:
- Anti-tick and pathogen transmission blocking vaccines.
- Resistance to Ticks and the Path to Anti-Tick and Transmission Blocking Vaccines.
- Field evaluation of a novel oral reservoir-targeted vaccine against Borrelia burgdorferi utilizing an inactivated whole-cell bacterial antigen expression vehicle.
- Administration of an Orally Delivered Substrate Targeting a Mammalian Zoonotic Pathogen Reservoir Population: Novel Application and Biomarker Analysis.
- Oral Delivery of Bacillus subtilis Expressing Chicken NK-2 Peptide Protects Against Eimeria acervulina Infection in Broiler Chickens.
- Effect of orally administered B. subtilis-cNK-2 on growth performance, immunity, gut health, and gut microbiome in chickens infected with Eimeria acervulina and its potential as an alternative to antibiotics.
- Orally delivered Bacillus subtilis expressing chicken NK-2 peptide stabilizes gut microbiota and enhances intestinal health and local immunity in coccidiosis-infected broiler chickens.
- Basic Science:
- Sexually dimorphic tumor suppression by small mitochondrial Arf.
- Small mitochondrial Arf (smArf) protein corrects p53-independent developmental defects of Arf tumor suppressor-deficient mice.
- Functional profiling of receptor tyrosine kinases and downstream signaling in human chondrosarcomas identifies pathways for rational targeted therapy.
- Src kinases in chondrosarcoma chemoresistance and migration: dasatinib sensitises to doxorubicin in TP53 mutant cells.
- Three new chondrosarcoma cell lines: one grade III conventional central chondrosarcoma and two dedifferentiated chondrosarcomas of bone.
- Cartilage tumour progression is characterized by an increased expression of heparan sulphate 6O-sulphation-modifying enzymes.
- Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome.
- A screening-based approach identifies cell cycle regulators AURKA, CHK1 and PLK1 as targetable regulators of chondrosarcoma cell survival.
- Translational Science:
- Preclinical and Pilot Study of Type I FLT3 Tyrosine Kinase Inhibitor, Crenolanib, with Sorafenib in Acute Myeloid Leukemia and FLT3-Internal Tandem Duplication.
- Hypoxia-induced upregulation of BMX kinase mediates therapeutic resistance in acute myeloid leukemia.
- Kinome profiling of chondrosarcoma reveals SRC-pathway activity and dasatinib as option for treatment.
- Update on targets and novel treatment options for high-grade osteosarcoma and chondrosarcoma.
- An orthotopic mouse model for chondrosarcoma of bone provides an in vivo tool for drug testing.
- Screening for potential targets for therapy in mesenchymal, clear cell, and dedifferentiated chondrosarcoma reveals Bcl-2 family members and TGFβ as potential targets.
- Bcl-xl as the most promising Bcl-2 family member in targeted treatment of chondrosarcoma.
- Restoration of chemosensitivity for doxorubicin and cisplatin in chondrosarcoma in vitro: BCL-2 family members cause chemoresistance.
- Targeting survivin as a potential new treatment for chondrosarcoma of bone.
- Clinical Epidemiology
- A High-risk Haplotype for Premature Menopause in Childhood Cancer Survivors Exposed to Gonadotoxic Therapy.
- Genetic Risk for Subsequent Neoplasms Among Long-Term Survivors of Childhood Cancer.
- Estimated number of adult survivors of childhood cancer in United States with cancer-predisposing germline variants.
- Interindividual variation in ovarian reserve after gonadotoxic treatment in female childhood cancer survivors – a genome-wide association study: results from PanCareLIFE.
- Premature Ovarian Insufficiency in Childhood Cancer Survivors: A Report From the St. Jude Lifetime Cohort.
- Predicting acute ovarian failure in female survivors of childhood cancer: a cohort study in the Childhood Cancer Survivor Study (CCSS) and the St Jude Lifetime Cohort (SJLIFE).
- Outcomes of pediatric patients with therapy-related myeloid neoplasms.
- A polygenic score for acute vaso-occlusive pain in pediatric sickle cell disease.
- Possible modification of BRSK1 on the risk of alkylating chemotherapy-related reduced ovarian function.
- Effect of Genetic Variation in CYP450 on Gonadal Impairment in a European Cohort of Female Childhood Cancer Survivors, Based on a Candidate Gene Approach: Results from the PanCareLIFE Study.
- A relationship between the incremental values of area under the ROC curve and of area under the precision-recall curve.
- Genome-wide search for higher order epistasis as modifiers of treatment effects on bone mineral density in childhood cancer survivors.
- Statistical Modeling
- Spatial Prediction of Coxiella burnetii Outbreak Exposure via Notified Case Counts in a Dose-Response Model.
- Use of a Dose-Response Model to Study Temporal Trends in Spatial Exposure to Coxiella burnetii: Analysis of a Multiyear Outbreak of Q Fever.
- Exposure to low doses of Coxiella burnetii caused high illness attack rates: Insights from combining human challenge and outbreak data.
- Human dose response relation for airborne exposure to Coxiella burnetii.
- Health Economic Outcomes Research
- The pathogen- and incidence-based DALY approach: an appropriate [corrected] methodology for estimating the burden of infectious diseases.
- Comparing the impact of two concurrent infectious disease outbreaks on The Netherlands population, 2009, using disability-adjusted life years.
- Measuring underreporting and under-ascertainment in infectious disease datasets: a comparison of methods.
- The disease burden of hepatitis B, influenza, measles and salmonellosis in Germany: first results of the burden of communicable diseases in Europe study.
Orange LLC Consulting 